Position: Postdoctoral Fellow in Cell Biology at Lund University

Position: Postdoctoral Fellow in Cell Biology at Lund University

The interdisciplinary Blom Research Group, Faculty of Medicine, Lund University, is recruiting a postdoctoral fellow with appropriate training and documented publication experience in cell biology or metabolic research.

The selected candidate will become an integral part of a research project focused on exploring the unconventional functions of two complement proteins, C3 and CD59, in the pathophysiology of pancreatic cells, especially in relation to the development of diabetes. This multifaceted project includes investigations into gene regulation, beta cell differentiation, cellular metabolism, discovery of novel protein interactions, and modulation of autophagy pathways.

Group home page:

https://www.protein-chemistry.lu.se

Postdoctoral training

This collaborative project provides an excellent platform for comprehensive training in a range of advanced methodologies. These include cutting-edge technologies such as advanced flow cytometry, confocal microscopy, molecular methodologies, including CRISPR/Cas-9 gene editing, investigations of protein interactions, and specialized assays designed for beta cell research. Depending on the candidate’s preferences, there will also be opportunities to gain proficiency in working with mouse models of diabetes.

Furthermore, the appointed fellow will be actively involved in disseminating his or her research findings by participating in scientific conferences and collaborating with distinguished scientists and clinical partners specializing in metabolic research. The project will be implemented within the framework of the Diabetes Center at Lund University, a dynamic center of excellence in this field.

www.ludc.lu.se

Our research group specializes in the study of innate immunity, with a particular focus on its role in both physiological and pathological processes, including diabetes. We are excited to deliver a stimulating project that not only includes state-of-the-art equipment, but also provides exceptional educational prospects. This project is part of our dynamic, interdisciplinary research team, renowned for its outstanding reputation and collaborative work culture that promotes teamwork.

Most importantly, the selected candidate will have the invaluable opportunity to work closely with our group leader within a collaborative research environment. This mentorship and collaboration will play a pivotal role not only in shaping and improving the project but also in guiding the candidate towards achieving their career aspirations.

Lund University and surrounding areas

Lund University, located in southern Sweden, is repeatedly ranked among the top 100 universities in the world. The university has 40,000 students and more than 8,000 employees in Lund, Helsingborg and Malmö. Our laboratory is located at the Medical Campus of Skane University Hospital (SUS) in Malmö with good public transport links to both Lund and Copenhagen (25 minutes to Copenhagen Airport). The city is culturally diverse and offers many recreational opportunities within the city and in neighboring counties. Candidates do not need to acquire Swedish language skills as most Swedes can communicate easily in English.

personal file

The candidate must hold a PhD preferentially in the area of ​​diabetes research, cell biology or related discipline, and must have completed the PhD within 3 years of starting the appointment.

Having prior experience in the following areas can be extremely beneficial for this role: cell biology, diabetes research, beta cell differentiation, proficiency in microscopy techniques, hands-on experience with mouse models, and a strong background in bioinformatics analysis, especially in RNA (RNA). Sequencing and ChIP sequencing.

Applicants must be highly motivated, able to work independently and collaboratively, and be creative and communicative.

Fluency in written and spoken English is mandatory.

Candidates should email their applications to the professor. Anna Blom (anna.blom@med.lu.se). Be sure to include a resume, list of publications, and email addresses for two references. The deadline is December 30, 2023.

Start date is flexible.

Selected recent publications from the collection relevant to the project

King B.C., Kulak K., Krus U., Rosberg R., Golec E., Wozniak K., Gomez M.F., Zhang E., O’Connell D., Renström E., and Blom A.M. (2019) Complement C3 protects against Autophagy-associated beta cell death via ATG16L1 interaction and regulation of autophagy., Cell Metabolism, 29, 202-210.

Kremlitzka M., Colineau L., Nowacka AA, Mohlin FC, Wozniak K., Blom AM and King BC, (2022) Alternative translation and retrotransposition of cytosolic C3 cells that detect cellular invading bacteria., Cell. mall. Life Sciences, 76:291.

Golec E, Ekström A, Noga M, Omar-Hmeadi M, Lund PE, Villoutreix BO, Krus U, Wozniak K, Korsgren O, Renström E, Barg S, King BC and Blom AM (2022) Alternative splicing encodes CD59 isoforms. New intracellular pathways that mediate insulin secretion are upregulated in diabetic islets. Proc Natl Acad Sci USA (PNAS), 119, e2120083119.

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