Distilling the causal relationship between physical activity traits and obesity via Mendelian randomization

Distilling the causal relationship between physical activity traits and obesity via Mendelian randomization

  • Fang, K., Mu, M., Liu, K. & He, Y. Screen time and overweight/obesity in children: a systematic review and meta-analysis. Developing child care health. 45744-753 (2019).

    Article in PubMed Google Scholar

  • Lee, I. M., Djoussé, L., Sesso, H. D., Wang, L. & Buring, J. E. Physical activity and overweight prevention. Gamma 3031173-1179 (2010).

    CAS article PubMed PubMed Central Google Scholar

  • Ekelund, U., Brage, S., Besson, H., Sharp, S. & Wareham, N. J. Time spent sitting and weight gain in healthy adults: reverse or bidirectional causality? I be. J. Clin. Notre. 88612-617 (2008).

    Article CAS PubMed Google Scholar

  • Baron Gibbs, B. et al. Bidirectional 10-year associations of sedentary behavior and accelerometer-measured activity categories with weight among middle-aged adults. Int. J obis. 44559-567 (2020).

    Article Google Scholar

  • Du, H. et al. Physical activity and sedentary leisure time and their association with body mass index, waist circumference and body fat percentage in 0.5 million adults: the China Kadoorie Biobank study. I be. J. Clin. Notre. 97487-496 (2013).

    CAS article PubMed PubMed Central Google Scholar

  • Strasser, B. Physical activity in obesity and metabolic syndrome. annals. New York Acad. Sci-fi. 1281141-159 (2013).

    Article Google Scholar

  • Sanderson, E. et al. Mendelian randomization. Nat. Rev. Ignition Methods 26 (2022).

    CAS article PubMed PubMed Central Google Scholar

  • Smith, G.D. & Ebrahim, S. “Mendelian randomization”: can genetic epidemiology contribute to understanding the environmental determinants of disease? Int. J. and Baimol. 321-22 (2003).

    Article in PubMed Google Scholar

  • Carrasquilla, G.D., García-Ureña, M., Fall, T., Sørensen, T.I. & Kilpeläinen, T.O. Mendelian randomization suggests a bidirectional causal relationship between physical inactivity and obesity. Elevy 11e70386 (2022).

    CAS article PubMed PubMed Central Google Scholar

  • Richmond, R. C. et al. Assessing causality in the relationship between childhood obesity and physical activity levels: a Mendelian randomization analysis. PLOS Med. 11e1001618 (2014).

    Article PubMed PubMed Central Google Scholar

  • Wang, Z. et al. Genome-wide association analyzes of physical activity and sedentary behavior provide insight into underlying mechanisms and roles in disease prevention. Nat. Genet. 541332-1344 (2022).

    CAS article PubMed PubMed Central Google Scholar

  • Yingo, L. et al. Meta-analysis of genome-wide association studies of height and body mass index in 700,000 individuals of European descent. Hmm. mall. Genet. 273641–3649 (2018).

    CAS article PubMed PubMed Central Google Scholar

  • Lee, JJ et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nat. Genet. 501112-1121 (2018).

    CAS article PubMed PubMed Central Google Scholar

  • Morrison, J., Knoblauch, N., Marcus, J. H., Stephens, M. & He, X. Mendelian randomization accounting for linked and unlinked pleiotropic effects using genome-wide summary statistics. Nat. Genet. 52740-747 (2020).

    CAS article PubMed PubMed Central Google Scholar

  • Verbanck, M., Chen, C.-Y., Neale, B. & Do, R. Uncovering large-scale horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat. Genet. 50693-698 (2018).

    CAS article PubMed PubMed Central Google Scholar

  • Burgess, S., Butterworth, A. & Thompson, S. G. Mendelian randomization analysis with multiple genetic variants using summed data. Genet. And Bael. 37658-665 (2013).

    Article PubMed PubMed Central Google Scholar

  • Hartwig, F.P., Davey Smith, G. & Bowden, J. Robust inference in summary Mendelian random data via the zero conditional polymorphism assumption. Int. J. and Baimol. 461985-1998 (2017).

    Article PubMed PubMed Central Google Scholar

  • Hemani, G. et al. Automating Mendelian randomization through machine learning to build a hypothesized causal map of human phenomena. com.bioRxiv173682 (2017).

  • Darrous, L., Mounier, N. & Kutalik, Z. Simultaneous estimation of bidirectional causal effects and inherited confounding from GWAS summary statistics.Nat. common. 127274 (2021).

    CAS article PubMed PubMed Central Google Scholar

  • Cheng, J. et al. LD Hub: A central database and web interface for performing LD score regression that leverages the potential of summary-level GWAS data for SNP inheritance and genetic association analysis. Bioinformatics 33272-279 (2016).

    Article PubMed PubMed Central Google Scholar

  • Sadrarif, II et al. Navigating oversampling, the winner’s curse, and weak instrument bias in Mendelian randomization studies using the UK Biobank. medRxiv2021.06.28.21259622 (2021).

  • Sanderson, E., Spiller, W. & Bowden, J. Testing and correcting weak and multivariate instruments in multivariable Mendelian randomization in two samples. state. with. 405434-5452 (2021).

    Article PubMed PubMed Central Google Scholar

  • Hemani, G., Tilling, K., & Davey Smith, G. Guiding causality between imprecisely measured traits using GWAS summary data. PLoS Genet. 13e1007081 (2017).

    Article PubMed PubMed Central Google Scholar

  • Defays, D. An efficient algorithm for the full correlation method. account. C. 20364-366 (1977).

    Article Google Scholar

  • Clementidis, Y. C. et al. A genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE. Int. J obis. 421161-1176 (2018).

    Article CAS Google Scholar

  • Schnurr, TM, Stallknecht, BM, Sørensen, TIA, Kilpeläinen, TO & Hansen, T. Evidence for shared genetics between physical activity, sedentary behavior and obesity-related traits. Obesity. pastor. 22e13182 (2021).

    Article in PubMed Google Scholar

  • Doherty, A. et al. GWAS identifies 14 sites of physical activity and sleep duration measured by the device. Nat. common. 95257 (2018).

    Article PubMed PubMed Central Google Scholar

  • Pollitt, S. L. et al. Meta-analysis of genome-wide association studies of body fat distribution in 694,649 individuals of European ancestry. Hmm. mall. Genet. 28166-174 (2019).

    Article CAS PubMed Google Scholar

  • Donnelly, J. et al. Physical Activity Across the Curriculum (PAAC): A randomized controlled trial to promote physical activity and reduce overweight and obesity in primary school children. It is forbidden. Med. 49336-341 (2009).

    Article Google Scholar

  • Donnelly, J. et al. Physical activity, fitness, cognitive function, and academic achievement in children: a systematic review. Med. Sci-fi. Playing sports 481197-1222 (2016).

    Article Google Scholar

  • Plowman, M. Exercise is food for the brain: effects of physical activity on cognitive function. Dave. Neurorehabilitation. 11236-240 (2008).

    Article in PubMed Google Scholar

  • Droomers, M., Schrijvers, CT & Mackenbach, JP Educational level and low leisure-time physical activity: predictors from the longitudinal GLOBE study. J. and Baimol. community Health 55562-568 (2001).

    CAS article PubMed PubMed Central Google Scholar

  • Cohen, A. K., Rai, M., Rehkopf, D. H. & Abrams, B. Educational attainment and obesity: a systematic review. Obesity. pastor. 14989-1005 (2013).

    CAS article PubMed PubMed Central Google Scholar

  • Davies, N.M. et al. Within family Mendelian randomized studies. Hmm. mall. Genet. 28R170–R179 (2019).

    Article CAS PubMed Google Scholar

  • Brompton, B. et al. Avoid family mating, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.Nat Common. 113519 (2020).

    CAS article PubMed PubMed Central Google Scholar

  • Howe, L.J. et al. Educational attainment, health outcomes, and mortality: a Mendelian randomization study within siblings. medRxiv 1122268884 (2022).

    Google Scholar

  • Howe, L.J. et al. Genome-wide association analyzes within siblings reduce bias in estimates of direct genetic effects. Nat. Genet. 54581-592 (2022).

    CAS article PubMed PubMed Central Google Scholar

  • Sanderson, E., Smith, Davey, Windmeijer, G., Bowden, F. & An, J. Examining multivariate Mendelian randomization in one-sample and two-sample summary data settings. Int. J. and Baimol. 48713-727 (2019).

    Article in PubMed Google Scholar

  • Schnur, T. M. et al. Genetic predisposition to obesity is associated with increased objectively assessed sitting time in young children. Int. J obis. 42111-114 (2018).

    Article CAS Google Scholar

  • Ramadan, F. A. et al. Association of sedentary and physical activity behaviors with body composition: a genome-wide association and Mendelian randomization study. BMJ Open Calisthenics Med. 8e001291 (2022).

    Article Google Scholar

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